Laboratory of Growth Regulators
Laboratory of Growth Regulators has been created in 1995 as a joined facility of the Faculty of Science, Palacký University (www.upol.cz) and the Institute of Experimental Botany of the Czech Academy of Sciences (www.ueb.cas.cz).
Research program of the laboratory is aimed primary at small molecules that regulate cell division cycle, proliferation and growth of both plant and animal cells. Namely cytokinins and cytokinin-derived purine inhibitors of cyclin-dependent kinases belongs to the most intensively studied compounds. The representative of the latter, roscovitine (CYC202, seliciclib), already undergoes phase II clinical trials in patients as a novel anticancer drug held by Cyclacel Ltd (for more information see actual Press Release).
Our multidisciplinary research team is composed of experienced plant physiologists, biochemists as well as organic and analytical chemists. Many students are involved in the research during their pregradual and postgraduate studies of botany, analytical and organic chemistry, biochemistry or medicinal biology, respectively.
Laboratory of Growth Regulators guarantees the teaching for biological study programs. Members of the laboratory give lectures from general botany, plant physiology, microbiology, chemistry, molecular biology, including practical courses and seminars.
Several reseach projects are in progress in colaboration with international partners (University of Berlin, Germany; Swedish University of Agricultural Sciences, Sweden; University of Natal Pietermaritzburg, South Africa; Vienna Medical University, Austria).
Workers
head of the laboratorysenior scientist
- Prof. Mgr. Ondřej Novák Ph.D.
deputy head of the laboratoryscientist
- Prof. ing. Miroslav Strnad CSc.
senior scientist
scientist
- RNDr. Martin Fellner Ph.D.
- RNDr. Miroslav Kvasnica Ph.D.
- Mgr. Marie Kvasnicová
- Ing. Ludmila Ohnoutková Ph.D.
- Mgr. Jana Oklešťková PhD.
- Jiří Pospíšil
- Jitka Široká
- doc. Mgr. Danuše Tarkowská Ph.D.
scientific assistant
graduated technical assistant
- Mgr. Ota Blahoušek
- Ing. Věra Doleželová
- Ivan Petřík
assistant
- Jitka Hansgutová DiS.
- Mgr. Pavel Jaworek Ph.D.
maintenance
Research projects
Publications
2017
- NATURE COMMUNICATIONS 8 14752 2017
- JOURNAL OF PLANT PHYSIOLOGY 214 53-63 2017 (External fulltext)
-
Microscale magnetic microparticle-based immunopurification of cytokinins from Arabidopsis root apex.PLANT JOURNAL 85 1065-1075 2017
- STEROIDS 2017
- Mechanisms behind phytohormonal signalling and crop abiotic stress tolerance 265-279 2017
- PLOS ONE 12 e0170715 2017 (External fulltext)
2016
- BMC PLANT BIOLOGY 16 198 2016 (External fulltext)
- PHYTOCHEMISTRY 230-237 2016 (External fulltext)
- EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 110 291-301 2016 Fulltext: public PDF link
- NEW BIOTECHNOLOGY 33 614-624 2016