Čeština
EnglishJOURNAL OF MEDICINAL CHEMISTRY
3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models
Jorda R., Havlíček L., Šturc A., Tušková D., Daumová L., Alam M., Škerlová J., Nekardová M., Peřina M., Pospíšil T., Široká J., Urbánek L., Pachl P., Řezáčová P., Strnad M., Klener P., Kryštof V.JOURNAL OF MEDICINAL CHEMISTRY 62 : 4606-4623 , 2019
Klíčová slova:
Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine: Evaluation of a Novel Selective Inhibitor of Cyclin-Dependent Kinases with Antiproliferative Activity
Jorda R., Havlicek L., McNae I.W., Walkinshaw M.D., Voller J., Sturc A., Navratilova J., Kuzma M., Mistrik M., Bartek J., Strnad M., Krystof V.JOURNAL OF MEDICINAL CHEMISTRY 54 : 2980-2993 , 2011
Klíčová slova:
New Analogues of the Potent Cytotoxic Saponin OSW-1
Wojtkielewicz, A.; Dlugosz, M.; Maj, J.; Morzycki, J.W.; Nowakowski, M.; Renkiewicz, J.; Strnad, Miroslav; Swaczynová, Jana; Wilczewska, A.Z.; Wojcik, J.JOURNAL OF MEDICINAL CHEMISTRY 50 [15] : 3667-3673 , 2007
Klíčová slova: NATURAL PRODUCT OSW-1; ANTITUMOR SAPONIN; ORNITHOGALUM-SAUNDERSIAE
4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects
Kryštof, Vladimír; Cankař, Petr; Fryšová, I.; Slouka, J.; Kontopidis, G.; Džubák, P.; Hajdúch, M.; Srovnal, J.; de Azevedo Jr., W.F.; Orság, Martin; Paprskářová, Martina; Rolčík, Jakub; Látr, Aleš; Fischer, P.M.; Strnad, MiroslavJOURNAL OF MEDICINAL CHEMISTRY 49 [22] : 6500-6509 , 2006
Klíčová slova: DEPENDENT KINASE INHIBITORS; POLYMERASE-II TRANSCRIPTION; TUMOR-NECROSIS-FACTOR
Synthesis and cytotoxic activity of substituted 2-phenyl-3-hydroxy-4(1H)-quinolinones-7-carboxylic acids and their phenacyl esters
Soural, M.; Hlaváč, J.; Hradil, P.; Fryšová, I.; Hajdúch, M.; Bertolasi, V.; Maloň, MichalJOURNAL OF MEDICINAL CHEMISTRY 41 [4] : 467-474 , 2006
Klíčová slova: Quinolinone; Cytotoxic activity; X-ray structure