Čeština
EnglishBeta-1,2,3-triazolyl-nucleosides as nicotinamide riboside mimics
Amigues E.J., Armstrong E., Dvorakova M., Migaud M.E., Huang M.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 28 [3]: 238-259, 2009
Keywords: Nucleoside; nucleotide; sirtuin, inhibition
Abstract: The synthesis of a series of pyridine- and piperidine-substituted 1,2,3-triazolides linked to a riboside moiety is described. The presence of a triazolide substituent on the pyridine moiety permitted the facile reduction of the latter under mild hydrogenation conditions. These analogues were modelled as to define their similarity to nicotinamide riboside and quantify their ability to bind NAD-dependent protein deacetylases.
DOI:
Fulltext: contact IEB authors
IEB authors: Marcela Dvořáková
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 28 [3]: 238-259, 2009
Keywords: Nucleoside; nucleotide; sirtuin, inhibition
Abstract: The synthesis of a series of pyridine- and piperidine-substituted 1,2,3-triazolides linked to a riboside moiety is described. The presence of a triazolide substituent on the pyridine moiety permitted the facile reduction of the latter under mild hydrogenation conditions. These analogues were modelled as to define their similarity to nicotinamide riboside and quantify their ability to bind NAD-dependent protein deacetylases.
DOI:
Fulltext: contact IEB authors
IEB authors: Marcela Dvořáková