Čeština
EnglishRecombinant cytokines from plants
Sirko A.,Vaněk T., Gora-Sochacka A., Redkiewicz P.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 12[6]: 3536-3552, 2011
Keywords: cytokines; pharmaceutical proteins; plant-based production systems; molecular farming; interleukins; transgenic plants
Abstract: Plant-based platforms have been successfully applied for the last two decades for the efficient production of pharmaceutical proteins. The number of commercialized products biomanufactured in plants is, however, rather discouraging. Cytokines are small glycosylated polypeptides used in the treatment of cancer, immune disorders and various other related diseases. Because the clinical use of cytokines is limited by high production costs they are good candidates for plant-made pharmaceuticals. Several research groups explored the possibilities of cost-effective production of animal cytokines in plant systems. This review summarizes recent advances in this field.
DOI:
IEB authors: Tomáš Vaněk
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 12[6]: 3536-3552, 2011
Keywords: cytokines; pharmaceutical proteins; plant-based production systems; molecular farming; interleukins; transgenic plants
Abstract: Plant-based platforms have been successfully applied for the last two decades for the efficient production of pharmaceutical proteins. The number of commercialized products biomanufactured in plants is, however, rather discouraging. Cytokines are small glycosylated polypeptides used in the treatment of cancer, immune disorders and various other related diseases. Because the clinical use of cytokines is limited by high production costs they are good candidates for plant-made pharmaceuticals. Several research groups explored the possibilities of cost-effective production of animal cytokines in plant systems. This review summarizes recent advances in this field.
DOI: